cell stage on the number of total and Biology Diagrams Background Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during mitosis. It also acts as a mitotic regulator, controlling chromosome segregation. In this study, we investigated whether the transactivation
Heat shock causes proteotoxic stress that induces various cellular responses, including delayed mitotic progression and the generation of an aberrant number of chromosomes. In this study, heat shock Heat shock is a physiological and environmental stress that leads to the denaturation and inactivation of cellular proteins and is used in hyperthermia cancer therapy. Previously, we revealed that mild heat shock (42 °C) delays the mitotic progression by activating the spindle assembly checkpoint (S … Furthermore, the most famous transcription factor against temperature stress is heat shock transcription factor/heat shock factor (HSF). HSF was discovered as a transcription factor essential for the heat shock response. The heat shock response is a cellular protective mechanism against heat stress that was discovered by Ritossa in 1962.
Heat shock transcription factors demonstrate a distinct mode of ... Biology Diagrams
Here we show that the genome-wide transcriptional response to heat shock in mammals is rapid and dynamic and results in induction of several hundred and repression of several thousand genes. During interphase, another transcription factor, HSF2, collaborates with HSF1 to switch on expression of heat-shock genes. During mitosis, however, cells become more susceptible to stress because they curtail this induction of heat-shock genes.
Here, we show that mild heat shock, applied during mitosis, causes loss of dynamitin/p50 antibody staining from centrosomes and kinetochores. In addition, it induces division errors in most cells and in the remaining cells progression through mitosis is delayed.
Heat shock‐induced mitotic arrest requires heat shock protein 105 for ... Biology Diagrams
To define the mechanisms governing TF behavior during mitosis in mouse embryonic stem cells, we examined two related TFs: Heat Shock Factor 1 and 2 (HSF1 and HSF2). We found that HSF2 maintains site-specific binding genome-wide during mitosis, whereas HSF1 binding is somewhat decreased.
