Overview of the behaviors of cohesin and condensins during the cell Biology Diagrams Condensin and cohesin function in a number of processes independently of their classically defined roles, but the mechanisms that underlie these functions are poorly understood because disrupting either complex results in mitotic defects and lethality. Despite these hurdles, much has been learned through use of conditional, tissue-specific or
References 38, 43, 44, 50 and 51 provide intriguing suggestions for new roles of cohesin or condensin subunits in aspects of gene regulation, including silencing, chromatin insulator function and
Cohesin vs. Condensin - What's the Difference? Biology Diagrams
Condensins are proteins of vital importance, playing a fundamental role in the structural and functional organization of chromosomes. This comprehensive review touches on aspects of condensin cell type- and tissue-specific functions, relevance to human disease, and insights gained from biochemical and structural analysis, providing a global view of condensin biology. Condensin and cohesin complexes act in diverse nuclear processes in addition to their widely known roles in chromosome compaction and sister chromatid cohesion. Recent work has elucidated the contribution of condensin and cohesin to interphase genome organization, control of gene expression, metazoan development and meiosis.
Recent studies show that cohesin, condensin and their relatives are involved in a wide variety of chromosomal functions and their regulation, such as genomic imprinting, dosage compensation, and human congenital disorders [33, 44]. It is fascinating to investigate unidentified roles of cohesin and condensin during gametogenesis and early
Condensin Biology Diagrams
Function. While both cohesin and condensin are involved in chromosome organization, they have distinct functions. Cohesin plays a critical role in sister chromatid cohesion, ensuring that replicated chromosomes are held together until the appropriate time for their separation during cell division. It also participates in DNA repair and gene
